THCP, HHCPO, H4CBD and Others Classified as Narcotics

From June 3, 2024, several new cannabinoids will be officially classified as narcotics in France. This decision, made by the ANSM, follows an increase in reports of serious effects and detection of severe poisoning cases by the centers for evaluation and information on pharmacodependence-addictovigilance (CEIP-A). The goal: to protect public health against the emergence of substances with high addiction potential and serious risks to the body.

⚖️ Which cannabinoids are concerned?

🔬 Semi-synthetic cannabinoids

Semi-synthetic cannabinoids are derivatives of natural hemp molecules, chemically modified to enhance their psychoactive effects. They include:

• H4-CBD
• H2-CBD

🧪 Benzo[c]chromene core derivatives

These cannabinoids, close to THC, act directly on brain receptors CB1 and CB2. Their consumption exposes users to powerful and sometimes unpredictable effects. The new regulation includes:

• HHC (Hexahydrocannabinol)
• HHCO (HHC-Acetate)
• HHCP (Hexahydrocannabiphorol)
• HHCPO (HHCP-Acetate)
• THCP (Tetrahydrocannabiphorol)
• THCA (Tetrahydrocannabinolic acid)

⚗️ Synthetic cannabinoids

Entirely created in laboratories, these substances mimic the action of THC but in a much more intense way. They are now listed as narcotics:

• 5F-Cumyl-Pegaclone (5F-SGT-151)
• Cumyl-CH-Megaclone (SGT-270)
• 7APAICA
• 5F-7APAICA
• Cumyl-P7AICA
• 5F-Cumyl-P7AICA
• BZO-Hexoxizid (MDA-19)
• BZO-Poxizid (5C-MDA-19)

🚨 Why are these substances banned?

Immediate health risks

Effects observed after consumption are often rapid and violent:

• Vomiting, loss of consciousness, even coma
• Seizures, panic attacks or paranoia
• Tachycardia, hypertension, chest pain resembling a heart attack
• Kidney damage or neurological disorders

These effects are generally more intense than those of natural THC, due to a much higher concentration of active ingredients — often unknown to the consumer.

Addiction potential

Synthetic and semi-synthetic cannabinoids cause a rapid tolerance: the need to increase doses can lead to strong dependence and difficult withdrawal.

Uncertain composition and hidden risks

Many products sold online or in some CBD shops contain undeclared mixtures. Analyses show significant discrepancies between the actual composition and that announced on the packaging, exposing users to overdoses or unexpected toxic effects.

🧭 Monitoring and prevention

The ANSM and the CEIP-A maintain active monitoring of new cannabinoids circulating on the market. This monitoring allows for the rapid identification of dangerous substances and the adaptation of public health measures.

Most common consumption forms

These products are often marketed in attractive forms:

• Oils or resins
• Herb or vaporized flowers
• Sprays and e-liquids
• Gummies (candies)

They can be inhaled, vaped, or ingested, each mode of administration influencing the speed and strength of effects.

✅ Conclusion

The classification of these new cannabinoids as narcotics is an essential public health measure. It aims to limit public exposure to dangerous, poorly identified, and potentially addictive substances.

AMA Prévention encourages everyone to stay vigilant and to seek information from reliable sources before any consumption. In case of doubt or worrying symptoms, contact a healthcare professional immediately or the nearest poison control center.

📚 For more information: see the official ANSM article and find our prevention advice on ama-prevention.fr.